TY - GEN AU - Zou,James AU - Valiant,Gregory AU - Valiant,Paul AU - Karczewski,Konrad AU - Chan,Siu On AU - Samocha,Kaitlin AU - Lek,Monkol AU - Sunyaev,Shamil AU - Daly,Mark AU - MacArthur,Daniel G TI - Quantifying unobserved protein-coding variants in human populations provides a roadmap for large-scale sequencing projects SN - 2041-1723 PY - 2018///0920 KW - Algorithms KW - Alleles KW - Cohort Studies KW - Computational Biology KW - CpG Islands KW - Exome KW - Gene Frequency KW - Genetic Variation KW - Genome, Human KW - Humans KW - Linear Models KW - Mutation, Missense KW - Polymorphism, Single Nucleotide KW - Proteins KW - chemistry KW - Sequence Analysis, DNA N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S UR - https://doi.org/10.1038/ncomms13293 ER -