TY - GEN AU - Wong,Ee Tsin AU - Kogel,Ulrike AU - Veljkovic,Emilija AU - Martin,Florian AU - Xiang,Yang AU - Boue,Stephanie AU - Vuillaume,Gregory AU - Leroy,Patrice AU - Guedj,Emmanuel AU - Rodrigo,Gregory AU - Ivanov,Nikolai V AU - Hoeng,Julia AU - Peitsch,Manuel C AU - Vanscheeuwijck,Patrick TI - Evaluation of the Tobacco Heating System 2.2. Part 4: 90-day OECD 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects compared with cigarette smoke SN - 1096-0295 PY - 2017///0313 KW - Aerosols KW - Animals KW - Computational Biology KW - Consumer Product Safety KW - Electronic Nicotine Delivery Systems KW - adverse effects KW - Equipment Design KW - Female KW - Gene Expression Profiling KW - Gene Expression Regulation KW - drug effects KW - Genomics KW - Harm Reduction KW - Hot Temperature KW - Humans KW - Inhalation Exposure KW - Male KW - Pneumonia KW - chemically induced KW - Rats, Sprague-Dawley KW - Respiratory System KW - Risk Assessment KW - Smoke KW - Smoking KW - Systems Biology KW - Time Factors KW - Tobacco Industry KW - Tobacco Products KW - toxicity KW - Toxicity Tests KW - methods KW - Transcriptome N1 - Publication Type: Comparative Study; Journal Article UR - https://doi.org/10.1016/j.yrtph.2016.10.015 ER -