Progranulin Recruits HSP70 to β-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease. [electronic resource]
- EBioMedicine Nov 2016
- 212-224 p. digital
Publication Type: Journal Article
2352-3964
10.1016/j.ebiom.2016.10.010 doi
Animals Cell Line Disease Models, Animal Fibroblasts--drug effects Gaucher Disease--drug therapy Glucosylceramidase--metabolism HSP70 Heat-Shock Proteins--genetics Humans Intercellular Signaling Peptides and Proteins--genetics Lysosomal Membrane Proteins--metabolism Lysosomes--metabolism Mice Mice, Knockout Phenotype Progranulins Protein Aggregates Protein Binding Recombinant Proteins--pharmacology Stress, Physiological