TY  - GEN
AU  - Brown,Philip M
AU  - Pratt,Arthur G
AU  - Isaacs,John D
TI  - Mechanism of action of methotrexate in rheumatoid arthritis, and the search for biomarkers
SN  - 1759-4804
PY  - 2017///0612
KW  - Adenosine
KW  - metabolism
KW  - Antirheumatic Agents
KW  - pharmacology
KW  - Arthritis, Rheumatoid
KW  - drug therapy
KW  - Biomarkers
KW  - Cell Adhesion Molecules
KW  - drug effects
KW  - Cytokines
KW  - Eicosanoids
KW  - Folic Acid Antagonists
KW  - Humans
KW  - Metalloproteases
KW  - Methotrexate
KW  - Methylation
KW  - Pharmacogenomic Variants
KW  - genetics
KW  - Polymorphism, Single Nucleotide
KW  - Reactive Oxygen Species
KW  - Signal Transduction
KW  - Treatment Outcome
N1  - Publication Type: Journal Article; Review; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1038/nrrheum.2016.175
ER  -