Brown, Philip M <br/><br/>
Mechanism of action of methotrexate in rheumatoid arthritis, and the search for biomarkers.  [electronic resource] 

 -  Nature reviews. Rheumatology  12 2016 
 - 731-742 p.  digital 
<br/><br/> Publication Type: Journal Article; Review; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1759-4804 
<br/><br/><label>Standard No.: </label>10.1038/nrrheum.2016.175  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Adenosine--metabolism<br/>Antirheumatic Agents--pharmacology<br/>Arthritis, Rheumatoid--drug therapy<br/>Biomarkers<br/>Cell Adhesion Molecules--drug effects<br/>Cytokines--drug effects<br/>Eicosanoids--metabolism<br/>Folic Acid Antagonists--pharmacology<br/>Humans<br/>Metalloproteases--drug effects<br/>Methotrexate--pharmacology<br/>Methylation--drug effects<br/>Pharmacogenomic Variants--genetics<br/>Polymorphism, Single Nucleotide<br/>Reactive Oxygen Species--metabolism<br/>Signal Transduction--drug effects<br/>Treatment Outcome