TY  - GEN
AU  - Leung,Louis
AU  - Yang,Xin
AU  - Strelevitz,Timothy J
AU  - Montgomery,Justin
AU  - Brown,Matthew F
AU  - Zientek,Michael A
AU  - Banfield,Christopher
AU  - Gilbert,Adam M
AU  - Thorarensen,Atli
AU  - Dowty,Martin E
TI  - Clearance Prediction of Targeted Covalent Inhibitors by In Vitro-In Vivo Extrapolation of Hepatic and Extrahepatic Clearance Mechanisms
SN  - 1521-009X
PY  - 2018///0221
KW  - Algorithms
KW  - Animals
KW  - Drug Evaluation, Preclinical
KW  - Glutathione
KW  - metabolism
KW  - Hepatocytes
KW  - Humans
KW  - In Vitro Techniques
KW  - Male
KW  - Metabolic Clearance Rate
KW  - Mice, Inbred C57BL
KW  - Microsomes, Liver
KW  - Models, Biological
KW  - Pharmaceutical Preparations
KW  - blood
KW  - Plasma
KW  - Predictive Value of Tests
KW  - Protein Binding
KW  - Protein Kinase Inhibitors
KW  - Rats
KW  - Rats, Sprague-Dawley
KW  - Species Specificity
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1124/dmd.116.072983
ER  -