Leung, Louis <br/><br/>
Clearance Prediction of Targeted Covalent Inhibitors by In Vitro-In Vivo Extrapolation of Hepatic and Extrahepatic Clearance Mechanisms.  [electronic resource] 

 -  Drug metabolism and disposition: the biological fate of chemicals  01 2017 
 - 1-7 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1521-009X 
<br/><br/><label>Standard No.: </label>10.1124/dmd.116.072983  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Algorithms<br/>Animals<br/>Drug Evaluation, Preclinical<br/>Glutathione--metabolism<br/>Hepatocytes--metabolism<br/>Humans<br/>In Vitro Techniques<br/>Male<br/>Metabolic Clearance Rate<br/>Mice, Inbred C57BL<br/>Microsomes, Liver--metabolism<br/>Models, Biological<br/>Pharmaceutical Preparations--blood<br/>Plasma--metabolism<br/>Predictive Value of Tests<br/>Protein Binding<br/>Protein Kinase Inhibitors--blood<br/>Rats<br/>Rats, Sprague-Dawley<br/>Species Specificity