25-hydroxycholesterol contributes to cerebral inflammation of X-linked adrenoleukodystrophy through activation of the NLRP3 inflammasome. [electronic resource]
- Nature communications 10 2016
- 13129 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
2041-1723
10.1038/ncomms13129 doi
ATP Binding Cassette Transporter, Subfamily D, Member 1--genetics Adrenoleukodystrophy--chemically induced Animals Corpus Callosum--drug effects Fibroblasts--drug effects Gene Expression Hydroxycholesterols--metabolism Induced Pluripotent Stem Cells--drug effects Inflammasomes--drug effects Inflammation Injections, Intraventricular Liver X Receptors--genetics Male Mice Mice, Inbred C57BL Mice, Knockout NLR Family, Pyrin Domain-Containing 3 Protein--agonists Oligodendroglia--drug effects Primary Cell Culture Reactive Oxygen Species--metabolism Stereotaxic Techniques Steroid Hydroxylases--deficiency White Matter--drug effects