TY - GEN AU - Connor,Ashton A AU - Denroche,Robert E AU - Jang,Gun Ho AU - Timms,Lee AU - Kalimuthu,Sangeetha N AU - Selander,Iris AU - McPherson,Treasa AU - Wilson,Gavin W AU - Chan-Seng-Yue,Michelle A AU - Borozan,Ivan AU - Ferretti,Vincent AU - Grant,Robert C AU - Lungu,Ilinca M AU - Costello,Eithne AU - Greenhalf,William AU - Palmer,Daniel AU - Ghaneh,Paula AU - Neoptolemos,John P AU - Buchler,Markus AU - Petersen,Gloria AU - Thayer,Sarah AU - Hollingsworth,Michael A AU - Sherker,Alana AU - Durocher,Daniel AU - Dhani,Neesha AU - Hedley,David AU - Serra,Stefano AU - Pollett,Aaron AU - Roehrl,Michael H A AU - Bavi,Prashant AU - Bartlett,John M S AU - Cleary,Sean AU - Wilson,Julie M AU - Alexandrov,Ludmil B AU - Moore,Malcolm AU - Wouters,Bradly G AU - McPherson,John D AU - Notta,Faiyaz AU - Stein,Lincoln D AU - Gallinger,Steven TI - Association of Distinct Mutational Signatures With Correlates of Increased Immune Activity in Pancreatic Ductal Adenocarcinoma SN - 2374-2445 PY - 2017///0821 KW - Aged KW - CD8-Positive T-Lymphocytes KW - immunology KW - CTLA-4 Antigen KW - metabolism KW - Carcinoma, Pancreatic Ductal KW - genetics KW - DNA Breaks, Double-Stranded KW - drug effects KW - DNA Mismatch Repair KW - Fanconi Anemia Complementation Group N Protein KW - Female KW - Genes, BRCA1 KW - physiology KW - Genes, BRCA2 KW - Genetic Predisposition to Disease KW - Genome-Wide Association Study KW - Humans KW - Male KW - Middle Aged KW - Mutation KW - Nuclear Proteins KW - Pancreatic Neoplasms KW - Prognosis KW - Programmed Cell Death 1 Receptor KW - Retrospective Studies KW - Tumor Suppressor Proteins N1 - Publication Type: Journal Article UR - https://doi.org/10.1001/jamaoncol.2016.3916 ER -