TY  - GEN
AU  - Harrod,A
AU  - Fulton,J
AU  - Nguyen,V T M
AU  - Periyasamy,M
AU  - Ramos-Garcia,L
AU  - Lai,C-F
AU  - Metodieva,G
AU  - de Giorgio,A
AU  - Williams,R L
AU  - Santos,D B
AU  - Gomez,P J
AU  - Lin,M-L
AU  - Metodiev,M V
AU  - Stebbing,J
AU  - Castellano,L
AU  - Magnani,L
AU  - Coombes,R C
AU  - Buluwela,L
AU  - Ali,S
TI  - Genomic modelling of the ESR1 Y537S mutation for evaluating function and new therapeutic approaches for metastatic breast cancer
SN  - 1476-5594
PY  - 2017///0425
KW  - Antineoplastic Agents
KW  - therapeutic use
KW  - Breast Neoplasms
KW  - drug therapy
KW  - CRISPR-Cas Systems
KW  - Cell Proliferation
KW  - drug effects
KW  - Cyclin-Dependent Kinases
KW  - antagonists & inhibitors
KW  - Estrogen Antagonists
KW  - pharmacology
KW  - Estrogen Receptor alpha
KW  - genetics
KW  - Estrogens
KW  - Female
KW  - Gene Knock-In Techniques
KW  - Histones
KW  - metabolism
KW  - Humans
KW  - MCF-7 Cells
KW  - Mutation
KW  - Phosphorylation
KW  - Serine
KW  - Tamoxifen
KW  - analogs & derivatives
KW  - Cyclin-Dependent Kinase-Activating Kinase
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1038/onc.2016.382
ER  -