Harrod, A Genomic modelling of the ESR1 Y537S mutation for evaluating function and new therapeutic approaches for metastatic breast cancer. [electronic resource] - Oncogene 04 2017 - 2286-2296 p. digital Publication Type: Journal Article ISSN: 1476-5594 Standard No.: 10.1038/onc.2016.382 doi Subjects--Topical Terms: Antineoplastic Agents--therapeutic useBreast Neoplasms--drug therapyCRISPR-Cas SystemsCell Proliferation--drug effectsCyclin-Dependent Kinases--antagonists & inhibitorsEstrogen Antagonists--pharmacologyEstrogen Receptor alpha--geneticsEstrogens--pharmacologyFemaleGene Knock-In TechniquesHistones--metabolismHumansMCF-7 CellsMutationPhosphorylationSerine--metabolismTamoxifen--analogs & derivativesCyclin-Dependent Kinase-Activating Kinase