Degnan, Andrew P <br/><br/>
Discovery of Indazoles as Potent, Orally Active Dual Neurokinin 1 Receptor Antagonists and Serotonin Transporter Inhibitors for the Treatment of Depression.  [electronic resource] 

 -  ACS chemical neuroscience  12 2016 
 - 1635-1640 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1948-7193 
<br/><br/><label>Standard No.: </label>10.1021/acschemneuro.6b00337  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Administration, Oral<br/>Animals<br/>Antidepressive Agents--chemical synthesis<br/>Depressive Disorder--drug therapy<br/>Disease Models, Animal<br/>Dose-Response Relationship, Drug<br/>Drug Discovery<br/>Drug Evaluation, Preclinical<br/>Gerbillinae<br/>Humans<br/>Indazoles--chemical synthesis<br/>Mice<br/>Molecular Structure<br/>Neurokinin-1 Receptor Antagonists--chemical synthesis<br/>Rats<br/>Receptors, Neurokinin-1--metabolism<br/>Serotonin Plasma Membrane Transport Proteins--metabolism<br/>Selective Serotonin Reuptake Inhibitors--chemical synthesis<br/>Structure-Activity Relationship<br/>Transcriptional Regulator ERG--metabolism