TY - GEN AU - Kashyap,Trinayan AU - Argueta,Christian AU - Aboukameel,Amro AU - Unger,Thaddeus John AU - Klebanov,Boris AU - Mohammad,Ramzi M AU - Muqbil,Irfana AU - Azmi,Asfar S AU - Drolen,Claire AU - Senapedis,William AU - Lee,Margaret AU - Kauffman,Michael AU - Shacham,Sharon AU - Landesman,Yosef TI - Selinexor, a Selective Inhibitor of Nuclear Export (SINE) compound, acts through NF-κB deactivation and combines with proteasome inhibitors to synergistically induce tumor cell death SN - 1949-2553 PY - 2018///0223 KW - Active Transport, Cell Nucleus KW - drug effects KW - Animals KW - Antineoplastic Combined Chemotherapy Protocols KW - pharmacology KW - Bone Neoplasms KW - drug therapy KW - Bortezomib KW - Cell Death KW - Cell Line, Tumor KW - Cell Nucleus KW - Dose-Response Relationship, Drug KW - Drug Resistance, Neoplasm KW - Drug Synergism KW - Female KW - Fibrosarcoma KW - Humans KW - Hydrazines KW - Karyopherins KW - antagonists & inhibitors KW - Mice, Inbred ICR KW - Mice, SCID KW - NF-KappaB Inhibitor alpha KW - genetics KW - NF-kappa B KW - Osteosarcoma KW - Phosphorylation KW - Proteasome Endopeptidase Complex KW - metabolism KW - Proteasome Inhibitors KW - Proteolysis KW - RNA Interference KW - Receptors, Cytoplasmic and Nuclear KW - Signal Transduction KW - Time Factors KW - Transcription Factor RelA KW - Transfection KW - Triazoles KW - Exportin 1 Protein N1 - Publication Type: Comparative Study; Journal Article UR - https://doi.org/10.18632/oncotarget.12428 ER -