Clonal expansion of CD8 T cells in the systemic circulation precedes development of ipilimumab-induced toxicities. [electronic resource]
- Proceedings of the National Academy of Sciences of the United States of America 10 2016
- 11919-11924 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1091-6490
10.1073/pnas.1611421113 doi
Antineoplastic Agents, Immunological--adverse effects Antineoplastic Combined Chemotherapy Protocols--adverse effects Biomarkers CD8-Positive T-Lymphocytes--immunology Clinical Trials, Phase II as Topic Clonal Evolution--immunology Disease Susceptibility Drug-Related Side Effects and Adverse Reactions--diagnosis Humans Ipilimumab--adverse effects Lymphocyte Count Male Middle Aged Prostatic Neoplasms--complications Severity of Illness Index T-Lymphocyte Subsets--immunology Treatment Outcome