Acetyl-CoA carboxylase rewires cancer metabolism to allow cancer cells to survive inhibition of the Warburg effect by cetuximab. [electronic resource]
- Cancer letters 01 2017
- 39-49 p. digital
Publication Type: Journal Article
1872-7980
10.1016/j.canlet.2016.09.020 doi
AMP-Activated Protein Kinases--metabolism Acetyl-CoA Carboxylase--antagonists & inhibitors Adult Aged Aged, 80 and over Animals Antineoplastic Agents--pharmacology Antineoplastic Combined Chemotherapy Protocols--pharmacology Carcinoma, Squamous Cell--drug therapy Cell Line, Tumor Cell Proliferation--drug effects Cell Survival--drug effects Cetuximab--pharmacology Drug Resistance, Neoplasm Enzyme Inhibitors--pharmacology Female Glycolysis--drug effects Head and Neck Neoplasms--drug therapy Humans Hypoxia-Inducible Factor 1, alpha Subunit--genetics Lipolysis--drug effects Male Mice, Nude Middle Aged Mutation Phosphorylation RNA Interference Signal Transduction--drug effects Squamous Cell Carcinoma of Head and Neck Time Factors Transfection Xenograft Model Antitumor Assays