TY - GEN AU - Massey,Andrew J TI - Inhibition of ATR-dependent feedback activation of Chk1 sensitises cancer cells to Chk1 inhibitor monotherapy SN - 1872-7980 PY - 2017///0724 KW - Antineoplastic Combined Chemotherapy Protocols KW - pharmacology KW - Apoptosis KW - drug effects KW - Ataxia Telangiectasia Mutated Proteins KW - antagonists & inhibitors KW - Bone Neoplasms KW - drug therapy KW - Cell Proliferation KW - Checkpoint Kinase 1 KW - Colorectal Neoplasms KW - DNA Damage KW - DNA-Activated Protein Kinase KW - Dose-Response Relationship, Drug KW - HT29 Cells KW - Histones KW - metabolism KW - Humans KW - Indoles KW - Isoxazoles KW - Molecular Targeted Therapy KW - Nuclear Proteins KW - Osteosarcoma KW - Protein Kinase Inhibitors KW - Pyrazines KW - Pyridones KW - Signal Transduction KW - Time Factors N1 - Publication Type: Journal Article UR - https://doi.org/10.1016/j.canlet.2016.09.024 ER -