TY  - GEN
AU  - Doyle,Kevin
AU  - Lönn,Hans
AU  - Käck,Helena
AU  - Van de Poël,Amanda
AU  - Swallow,Steve
AU  - Gardiner,Philip
AU  - Connolly,Stephen
AU  - Root,James
AU  - Wikell,Cecilia
AU  - Dahl,Göran
AU  - Stenvall,Kristina
AU  - Johannesson,Petra
TI  - Discovery of Second Generation Reversible Covalent DPP1 Inhibitors Leading to an Oxazepane Amidoacetonitrile Based Clinical Candidate (AZD7986)
SN  - 1520-4804
PY  - 2017///0606
KW  - Administration, Oral
KW  - Animals
KW  - Benzoxazoles
KW  - administration & dosage
KW  - Cathepsin C
KW  - antagonists & inhibitors
KW  - Dogs
KW  - Dose-Response Relationship, Drug
KW  - Drug Discovery
KW  - Humans
KW  - Mice
KW  - Molecular Structure
KW  - Oxazepines
KW  - Protease Inhibitors
KW  - Rabbits
KW  - Rats
KW  - Structure-Activity Relationship
KW  - U937 Cells
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1021/acs.jmedchem.6b01127
ER  -