Doyle, Kevin <br/><br/>
Discovery of Second Generation Reversible Covalent DPP1 Inhibitors Leading to an Oxazepane Amidoacetonitrile Based Clinical Candidate (AZD7986).  [electronic resource] 

 -  Journal of medicinal chemistry  Oct 2016 
 - 9457-9472 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1520-4804 
<br/><br/><label>Standard No.: </label>10.1021/acs.jmedchem.6b01127  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Administration, Oral<br/>Animals<br/>Benzoxazoles--administration & dosage<br/>Cathepsin C--antagonists & inhibitors<br/>Dogs<br/>Dose-Response Relationship, Drug<br/>Drug Discovery<br/>Humans<br/>Mice<br/>Molecular Structure<br/>Oxazepines--administration & dosage<br/>Protease Inhibitors--administration & dosage<br/>Rabbits<br/>Rats<br/>Structure-Activity Relationship<br/>U937 Cells