TY - GEN AU - Müller,E AU - Bauer,S AU - Stühmer,T AU - Mottok,A AU - Scholz,C-J AU - Steinbrunn,T AU - Brünnert,D AU - Brandl,A AU - Schraud,H AU - Kreßmann,S AU - Beilhack,A AU - Rosenwald,A AU - Bargou,R C AU - Chatterjee,M TI - Pan-Raf co-operates with PI3K-dependent signalling and critically contributes to myeloma cell survival independently of mutated RAS SN - 1476-5551 PY - 2017///1009 KW - Apoptosis KW - genetics KW - Cell Line, Tumor KW - Cell Survival KW - Drug Resistance, Neoplasm KW - Enzyme Activation KW - Gene Expression KW - Gene Knockdown Techniques KW - Humans KW - Isoenzymes KW - Lenalidomide KW - MAP Kinase Signaling System KW - drug effects KW - Multiple Myeloma KW - Mutation KW - Phosphatidylinositol 3-Kinases KW - metabolism KW - Phosphorylation KW - Protein Binding KW - Protein Kinase Inhibitors KW - pharmacology KW - Proto-Oncogene Proteins B-raf KW - antagonists & inhibitors KW - RNA Interference KW - RNA, Small Interfering KW - Signal Transduction KW - TOR Serine-Threonine Kinases KW - Thalidomide KW - analogs & derivatives KW - ras Proteins N1 - Publication Type: Journal Article UR - https://doi.org/10.1038/leu.2016.264 ER -