Pan-Raf co-operates with PI3K-dependent signalling and critically contributes to myeloma cell survival independently of mutated RAS. [electronic resource]
- Leukemia 04 2017
- 922-933 p. digital
Publication Type: Journal Article
1476-5551
10.1038/leu.2016.264 doi
Apoptosis--genetics Cell Line, Tumor Cell Survival--genetics Drug Resistance, Neoplasm Enzyme Activation Gene Expression Gene Knockdown Techniques Humans Isoenzymes Lenalidomide MAP Kinase Signaling System--drug effects Multiple Myeloma--genetics Mutation Phosphatidylinositol 3-Kinases--metabolism Phosphorylation--drug effects Protein Binding Protein Kinase Inhibitors--pharmacology Proto-Oncogene Proteins B-raf--antagonists & inhibitors RNA Interference RNA, Small Interfering--genetics Signal Transduction TOR Serine-Threonine Kinases--metabolism Thalidomide--analogs & derivatives ras Proteins--genetics