TY - GEN AU - Higgins,Sarah J AU - Purcell,Lisa A AU - Silver,Karlee L AU - Tran,Vanessa AU - Crowley,Valerie AU - Hawkes,Michael AU - Conroy,Andrea L AU - Opoka,Robert O AU - Hay,John G AU - Quaggin,Susan E AU - Thurston,Gavin AU - Liles,W Conrad AU - Kain,Kevin C TI - Dysregulation of angiopoietin-1 plays a mechanistic role in the pathogenesis of cerebral malaria SN - 1946-6242 PY - 2017///1211 KW - Adenoviridae KW - metabolism KW - Angiopoietin-1 KW - Animals KW - Antimalarials KW - pharmacology KW - Artemisinins KW - Artesunate KW - Blood-Brain Barrier KW - pathology KW - Child, Preschool KW - Disease Models, Animal KW - Disease Susceptibility KW - Endothelial Cells KW - drug effects KW - Female KW - Gene Deletion KW - Humans KW - Infant KW - Kaplan-Meier Estimate KW - Kinetics KW - Malaria, Cerebral KW - etiology KW - Malaria, Falciparum KW - Male KW - Mice, Inbred C57BL KW - Phenotype KW - Plasmodium falciparum KW - Receptor, TIE-2 KW - Recombinant Proteins KW - Survival Analysis KW - Treatment Outcome KW - Uganda N1 - Publication Type: Journal Article; Randomized Controlled Trial UR - https://doi.org/10.1126/scitranslmed.aaf6812 ER -