TY  - GEN
AU  - Blain,Jean-François
AU  - Bursavich,Matthew G
AU  - Freeman,Emily A
AU  - Hrdlicka,Lori A
AU  - Hodgdon,Hilliary E
AU  - Chen,Ting
AU  - Costa,Don E
AU  - Harrison,Bryce A
AU  - Kapadnis,Sudarshan
AU  - Murphy,Deirdre A
AU  - Nolan,Scott
AU  - Tu,Zhiming
AU  - Tang,Cuyue
AU  - Burnett,Duane A
AU  - Patzke,Holger
AU  - Koenig,Gerhard
TI  - Characterization of FRM-36143 as a new γ-secretase modulator for the potential treatment of familial Alzheimer's disease
SN  - 1758-9193
PY  - 2017///1016
KW  - Alzheimer Disease
KW  - drug therapy
KW  - Amyloid Precursor Protein Secretases
KW  - metabolism
KW  - Amyloid beta-Peptides
KW  - Animals
KW  - Brain
KW  - drug effects
KW  - Cell Line, Tumor
KW  - Drug Evaluation, Preclinical
KW  - HEK293 Cells
KW  - HeLa Cells
KW  - Heterocyclic Compounds, 4 or More Rings
KW  - pharmacokinetics
KW  - Humans
KW  - Male
KW  - Mice
KW  - Mice, 129 Strain
KW  - Mutation
KW  - Neocortex
KW  - Nootropic Agents
KW  - Presenilin-1
KW  - genetics
KW  - Rats, Wistar
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1186/s13195-016-0199-5
ER  -