Blain, Jean-François <br/><br/>
Characterization of FRM-36143 as a new γ-secretase modulator for the potential treatment of familial Alzheimer's disease.  [electronic resource] 

 -  Alzheimer's research & therapy  08 2016 
 - 34 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1758-9193 
<br/><br/><label>Standard No.: </label>10.1186/s13195-016-0199-5  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Alzheimer Disease--drug therapy<br/>Amyloid Precursor Protein Secretases--metabolism<br/>Amyloid beta-Peptides--metabolism<br/>Animals<br/>Brain--drug effects<br/>Cell Line, Tumor<br/>Drug Evaluation, Preclinical<br/>HEK293 Cells<br/>HeLa Cells<br/>Heterocyclic Compounds, 4 or More Rings--pharmacokinetics<br/>Humans<br/>Male<br/>Mice<br/>Mice, 129 Strain<br/>Mutation<br/>Neocortex--drug effects<br/>Nootropic Agents--pharmacokinetics<br/>Presenilin-1--genetics<br/>Rats, Wistar