The antiandrogen flutamide is a novel aryl hydrocarbon receptor ligand that disrupts bile acid homeostasis in mice through induction of Abcc4. [electronic resource]
- Biochemical pharmacology Nov 2016
- 93-104 p. digital
Publication Type: Journal Article
1873-2968
10.1016/j.bcp.2016.08.021 doi
Animals Bile Acids and Salts--metabolism Cell Line, Tumor Flutamide--chemistry Gene Expression Regulation--drug effects Hepatocytes Homeostasis--drug effects Ligands Mice Mice, Inbred C57BL Mice, Knockout Models, Molecular Multidrug Resistance-Associated Proteins--genetics Protein Binding Protein Conformation Receptors, Aryl Hydrocarbon--metabolism