TY  - GEN
AU  - Masuda,Mari
AU  - Uno,Yuko
AU  - Ohbayashi,Naomi
AU  - Ohata,Hirokazu
AU  - Mimata,Ayako
AU  - Kukimoto-Niino,Mutsuko
AU  - Moriyama,Hideki
AU  - Kashimoto,Shigeki
AU  - Inoue,Tomoko
AU  - Goto,Naoko
AU  - Okamoto,Koji
AU  - Shirouzu,Mikako
AU  - Sawa,Masaaki
AU  - Yamada,Tesshi
TI  - TNIK inhibition abrogates colorectal cancer stemness
SN  - 2041-1723
PY  - 2018///0917
KW  - Adenomatous Polyposis Coli Protein
KW  - genetics
KW  - Administration, Oral
KW  - Aged
KW  - Animals
KW  - Azoxymethane
KW  - toxicity
KW  - Carcinogenesis
KW  - drug effects
KW  - Cell Line, Tumor
KW  - Cell Proliferation
KW  - Cell Transformation, Neoplastic
KW  - pathology
KW  - Colorectal Neoplasms
KW  - chemically induced
KW  - Crystallography, X-Ray
KW  - Female
KW  - Germinal Center Kinases
KW  - Humans
KW  - Imidazoles
KW  - pharmacology
KW  - Male
KW  - Mice
KW  - Mice, Inbred BALB C
KW  - Mice, Inbred C57BL
KW  - Mice, Knockout
KW  - Mice, Nude
KW  - Middle Aged
KW  - Mutation
KW  - Neoplastic Stem Cells
KW  - Protein Binding
KW  - Protein Kinase Inhibitors
KW  - Protein Serine-Threonine Kinases
KW  - antagonists & inhibitors
KW  - Quinazolines
KW  - Recombinant Proteins
KW  - Ubiquitin-Protein Ligases
KW  - Wnt Proteins
KW  - metabolism
KW  - Wnt Signaling Pathway
KW  - Xenograft Model Antitumor Assays
KW  - beta Catenin
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1038/ncomms12586
ER  -