TY  - GEN
AU  - Meulendijks,Didier
AU  - Henricks,Linda M
AU  - van Kuilenburg,André B P
AU  - Jacobs,Bart A W
AU  - Aliev,Abidin
AU  - Rozeman,Lisette
AU  - Meijer,Judith
AU  - Beijnen,Jos H
AU  - de Graaf,Hiltje
AU  - Cats,Annemieke
AU  - Schellens,Jan H M
TI  - Patients homozygous for DPYD c.1129-5923C>G/haplotype B3 have partial DPD deficiency and require a dose reduction when treated with fluoropyrimidines
SN  - 1432-0843
PY  - 2017///0606
KW  - Aged
KW  - Antimetabolites, Antineoplastic
KW  - administration & dosage
KW  - Capecitabine
KW  - DNA, Complementary
KW  - genetics
KW  - Dihydropyrimidine Dehydrogenase Deficiency
KW  - Dihydrouracil Dehydrogenase (NADP)
KW  - Female
KW  - Fluorouracil
KW  - Gene Expression
KW  - Genetic Variation
KW  - Genotype
KW  - Haplotypes
KW  - Humans
KW  - Introns
KW  - Male
KW  - Middle Aged
KW  - Mutation
KW  - Neoplasms
KW  - complications
KW  - Precision Medicine
KW  - Retrospective Studies
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1007/s00280-016-3137-0
ER  -