Kelly, Kevin Safety and Pharmacodynamics of the PDE4 Inhibitor Roflumilast in Advanced B-cell Malignancies. [electronic resource] - Clinical cancer research : an official journal of the American Association for Cancer Research Mar 2017 - 1186-1192 p. digital Publication Type: Clinical Trial, Phase I; Journal Article ISSN: 1557-3265 Standard No.: 10.1158/1078-0432.CCR-16-1207 doi Subjects--Topical Terms: AdultAgedAged, 80 and overAminopyridines--administration & dosageB-Lymphocytes--drug effectsBenzamides--administration & dosageCyclic Nucleotide Phosphodiesterases, Type 4--drug effectsCyclopropanes--administration & dosageDrug-Related Side Effects and Adverse Reactions--pathologyFemaleHumansMaleMaximum Tolerated DoseMiddle AgedNeoplasms--drug therapyPhosphatidylinositol 3-Kinases--geneticsPhosphodiesterase 4 Inhibitors--administration & dosagePhosphoinositide-3 Kinase Inhibitors