Lamie, Phoebe F

Novel N-substituted indole Schiff bases as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase enzymes: Synthesis, biological activities in vitro and docking study. [electronic resource] - European journal of medicinal chemistry Nov 2016 - 803-813 p. digital

Publication Type: Journal Article

1768-3254

10.1016/j.ejmech.2016.08.013 doi


Anti-Inflammatory Agents--chemical synthesis
Antineoplastic Agents--chemical synthesis
Arachidonate 5-Lipoxygenase--chemistry
Catalytic Domain
Cell Line, Tumor
Chemistry Techniques, Synthetic
Cyclooxygenase 1--metabolism
Cyclooxygenase 2--metabolism
Cyclooxygenase 2 Inhibitors--chemical synthesis
Drug Design
Humans
Indoles--chemical synthesis
Lipoxygenase Inhibitors--chemical synthesis
Molecular Docking Simulation
Schiff Bases--chemistry