TY - GEN AU - De Oliveira,Leandro Gonzaga AU - Figueiredo,Letîcia Aparecida AU - Fernandes-Cunha,Gabriella Maria AU - Marina Barcelos,De Miranda AU - Machado,Laser Antonio AU - Dasilva,Gisele Rodrigues AU - Sandra Aparecida Lima,De Moura TI - Methotrexate Locally Released from Poly(e-Caprolactone) Implants: Inhibition of the Inflammatory Angiogenesis Response in a Murine Sponge Model and the Absence of Systemic Toxicity SN - 1520-6017 PY - 2017///1010 KW - Acetylglucosaminidase KW - metabolism KW - Angiogenesis Inhibitors KW - administration & dosage KW - Animals KW - Anti-Inflammatory Agents KW - Cell Proliferation KW - Collagen KW - chemistry KW - Drug Delivery Systems KW - Drug Implants KW - Drug Liberation KW - Inflammation KW - drug therapy KW - Interleukin-6 KW - Macrophages KW - drug effects KW - Male KW - Methotrexate KW - Mice KW - Mice, Inbred BALB C KW - Neovascularization, Pathologic KW - Neutrophil Infiltration KW - Peroxidase KW - Polyesters KW - Tissue Distribution KW - Tumor Necrosis Factor-alpha N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1002/jps.24569 ER -