Glatthar, Ralf <br/><br/>
Discovery of Imidazoquinolines as a Novel Class of Potent, Selective, and in Vivo Efficacious Cancer Osaka Thyroid (COT) Kinase Inhibitors.  [electronic resource] 

 -  Journal of medicinal chemistry  08 2016 
 - 7544-60 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1520-4804 
<br/><br/><label>Standard No.: </label>10.1021/acs.jmedchem.6b00598  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Crystallography, X-Ray<br/>Dogs<br/>Dose-Response Relationship, Drug<br/>Drug Discovery<br/>Humans<br/>Imidazoles--chemical synthesis<br/>MAP Kinase Kinase Kinases--antagonists & inhibitors<br/>Male<br/>Models, Molecular<br/>Molecular Structure<br/>Protein Kinase Inhibitors--chemical synthesis<br/>Proto-Oncogene Proteins--antagonists & inhibitors<br/>Quinolines--chemical synthesis<br/>Rats<br/>Rats, Sprague-Dawley<br/>Structure-Activity Relationship<br/>Tumor Necrosis Factor-alpha--antagonists & inhibitors