TY - GEN AU - Kumar,Ajay AU - Corey,Catherine AU - Scott,Iain AU - Shiva,Sruti AU - D'Cunha,Jonathan TI - Minnelide/Triptolide Impairs Mitochondrial Function by Regulating SIRT3 in P53-Dependent Manner in Non-Small Cell Lung Cancer SN - 1932-6203 PY - 2017///0808 KW - Acetylation KW - Antineoplastic Agents, Alkylating KW - pharmacology KW - Apoptosis KW - drug effects KW - Carcinoma, Non-Small-Cell Lung KW - drug therapy KW - Diterpenes KW - Epoxy Compounds KW - Gene Expression Regulation, Neoplastic KW - Humans KW - Lung Neoplasms KW - Membrane Potential, Mitochondrial KW - Mitochondria KW - Organophosphates KW - Oxidative Stress KW - Phenanthrenes KW - RNA, Small Interfering KW - genetics KW - Reactive Oxygen Species KW - metabolism KW - Sirtuin 3 KW - antagonists & inhibitors KW - Tumor Cells, Cultured KW - Tumor Suppressor Protein p53 N1 - Publication Type: Journal Article UR - https://doi.org/10.1371/journal.pone.0160783 ER -