TY - GEN AU - Bruner,Katherine M AU - Murray,Alexandra J AU - Pollack,Ross A AU - Soliman,Mary G AU - Laskey,Sarah B AU - Capoferri,Adam A AU - Lai,Jun AU - Strain,Matthew C AU - Lada,Steven M AU - Hoh,Rebecca AU - Ho,Ya-Chi AU - Richman,Douglas D AU - Deeks,Steven G AU - Siliciano,Janet D AU - Siliciano,Robert F TI - Defective proviruses rapidly accumulate during acute HIV-1 infection SN - 1546-170X PY - 2017///0810 KW - Acute Disease KW - Adult KW - Aged KW - Anti-HIV Agents KW - therapeutic use KW - Bayes Theorem KW - CD4-Positive T-Lymphocytes KW - virology KW - Cohort Studies KW - Disease Progression KW - Female KW - HIV Infections KW - drug therapy KW - HIV-1 KW - Humans KW - Male KW - Middle Aged KW - Polymerase Chain Reaction KW - Proviruses KW - metabolism KW - Viral Load KW - Virus Latency KW - Virus Replication KW - Young Adult N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1038/nm.4156 ER -