TY - GEN AU - Pettilä,Ville AU - Merz,Tobias AU - Wilkman,Erika AU - Perner,Anders AU - Karlsson,Sari AU - Lange,Theis AU - Hästbacka,Johanna AU - Hjortrup,Peter Buhl AU - Kuitunen,Anne AU - Jakob,Stephan M AU - Takala,Jukka TI - Targeted tissue perfusion versus macrocirculation-guided standard care in patients with septic shock (TARTARE-2S): study protocol and statistical analysis plan for a randomized controlled trial SN - 1745-6215 PY - 2018///0205 KW - Arterial Pressure KW - drug effects KW - Biomarkers KW - blood KW - Cardiotonic Agents KW - therapeutic use KW - Cardiovascular Agents KW - adverse effects KW - Clinical Protocols KW - Combined Modality Therapy KW - Data Interpretation, Statistical KW - Europe KW - Feasibility Studies KW - Fluid Therapy KW - Hemodynamics KW - Humans KW - Lactic Acid KW - Microcirculation KW - Models, Statistical KW - Prospective Studies KW - Regional Blood Flow KW - Renal Replacement Therapy KW - Research Design KW - Respiration, Artificial KW - Sample Size KW - Shock, Septic KW - diagnosis KW - Time Factors KW - Treatment Outcome KW - Vasoconstrictor Agents N1 - Publication Type: Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1186/s13063-016-1515-x ER -