TY  - GEN
AU  - Wood,Michael R
AU  - Noetzel,Meredith J
AU  - Tarr,James C
AU  - Rodriguez,Alice L
AU  - Lamsal,Atin
AU  - Chang,Sichen
AU  - Foster,Jarrett J
AU  - Smith,Emery
AU  - Chase,Peter
AU  - Hodder,Peter S
AU  - Engers,Darren W
AU  - Niswender,Colleen M
AU  - Brandon,Nicholas J
AU  - Wood,Michael W
AU  - Duggan,Mark E
AU  - Conn,P Jeffrey
AU  - Bridges,Thomas M
AU  - Lindsley,Craig W
TI  - Discovery and SAR of a novel series of potent, CNS penetrant M4 PAMs based on a non-enolizable ketone core: Challenges in disposition
SN  - 1464-3405
PY  - 2017///0829
KW  - Allosteric Regulation
KW  - Animals
KW  - Central Nervous System
KW  - metabolism
KW  - Drug Discovery
KW  - Humans
KW  - Ketones
KW  - chemical synthesis
KW  - Molecular Structure
KW  - Receptor, Muscarinic M1
KW  - agonists
KW  - Structure-Activity Relationship
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural
UR  - https://doi.org/10.1016/j.bmcl.2016.07.042
ER  -