Shi, Puyu <br/><br/>
Met gene amplification and protein hyperactivation is a mechanism of resistance to both first and third generation EGFR inhibitors in lung cancer treatment.  [electronic resource] 

 -  Cancer letters  10 2016 
 - 494-504 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1872-7980 
<br/><br/><label>Standard No.: </label>10.1016/j.canlet.2016.07.021  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Acrylamides--pharmacology<br/>Aniline Compounds--pharmacology<br/>Animals<br/>Antineoplastic Agents--pharmacology<br/>Antineoplastic Combined Chemotherapy Protocols--pharmacology<br/>Apoptosis--drug effects<br/>Carcinoma, Non-Small-Cell Lung--drug therapy<br/>Cell Line, Tumor<br/>Cell Proliferation--drug effects<br/>Crizotinib<br/>Dose-Response Relationship, Drug<br/>Drug Resistance, Neoplasm--drug effects<br/>ErbB Receptors--antagonists & inhibitors<br/>Erlotinib Hydrochloride--pharmacology<br/>Female<br/>G1 Phase Cell Cycle Checkpoints--drug effects<br/>Gene Amplification<br/>Gene Expression Regulation, Neoplastic<br/>Humans<br/>Lung Neoplasms--drug therapy<br/>Mice, Nude<br/>Molecular Targeted Therapy<br/>Mutation<br/>Protein Kinase Inhibitors--pharmacology<br/>Proto-Oncogene Proteins c-met--genetics<br/>Pyrazoles--pharmacology<br/>Pyridines--pharmacology<br/>Pyrimidines--pharmacology<br/>RNA Interference<br/>Signal Transduction--drug effects<br/>Time Factors<br/>Transfection<br/>Tumor Burden--drug effects<br/>Xenograft Model Antitumor Assays