Ray Chaudhuri, Arnab
Replication fork stability confers chemoresistance in BRCA-deficient cells. [electronic resource]
- Nature 07 2016
- 382-7 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
1476-4687
10.1038/nature18325 doi
Animals
Carrier Proteins--genetics
Cell Line, Tumor
Cisplatin--pharmacology
DNA--biosynthesis
DNA Breaks, Double-Stranded
DNA Damage--drug effects
DNA Helicases--genetics
DNA Repair--drug effects
DNA Repair Enzymes--antagonists & inhibitors
DNA Replication--drug effects
DNA-Binding Proteins--antagonists & inhibitors
Drug Resistance, Neoplasm--drug effects
Embryonic Stem Cells--drug effects
Female
Gene Deletion
Genes, BRCA1
Genes, BRCA2
Homologous Recombination
MRE11 Homologue Protein
Mice
Neoplasms--genetics
Nuclear Proteins--deficiency
Poly (ADP-Ribose) Polymerase-1
Poly(ADP-ribose) Polymerase Inhibitors--pharmacology
Poly(ADP-ribose) Polymerases--genetics