An increase in negative supercoiling in bacteria reveals topology-reacting gene clusters and a homeostatic response mediated by the DNA topoisomerase I gene. [electronic resource]
- Nucleic acids research 09 2016
- 7292-303 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1362-4962
10.1093/nar/gkw602 doi
Benzodioxoles--pharmacology DNA Gyrase--genetics DNA Topoisomerases, Type I--biosynthesis DNA, Bacterial--drug effects DNA, Superhelical--drug effects Gene Expression Regulation, Bacterial--drug effects Genes, Bacterial--genetics Homeostasis--drug effects Microbial Viability--drug effects Multigene Family Phenanthrenes--pharmacology Streptococcus pneumoniae--drug effects Transcription, Genetic--drug effects Transcriptome--drug effects