TY - GEN AU - Zook,Phillip AU - Pathak,Harsh B AU - Belinsky,Martin G AU - Gersz,Lawrence AU - Devarajan,Karthik AU - Zhou,Yan AU - Godwin,Andrew K AU - von Mehren,Margaret AU - Rink,Lori TI - Combination of Imatinib Mesylate and AKT Inhibitor Provides Synergistic Effects in Preclinical Study of Gastrointestinal Stromal Tumor SN - 1557-3265 PY - 2018///0202 KW - Animals KW - Antineoplastic Agents KW - pharmacology KW - Cell Line, Tumor KW - Cell Survival KW - drug effects KW - Disease Models, Animal KW - Dose-Response Relationship, Drug KW - Drug Evaluation, Preclinical KW - Drug Synergism KW - Gastrointestinal Stromal Tumors KW - drug therapy KW - Gene Expression Profiling KW - Heterocyclic Compounds, 3-Ring KW - Humans KW - Imatinib Mesylate KW - Mice KW - Protein Kinase Inhibitors KW - Proto-Oncogene Proteins c-kit KW - antagonists & inhibitors KW - Signal Transduction KW - Survival Analysis KW - Tumor Burden KW - Exome Sequencing KW - Xenograft Model Antitumor Assays N1 - Publication Type: Journal Article UR - https://doi.org/10.1158/1078-0432.CCR-16-0529 ER -