TY  - GEN
AU  - Pisani,Leonardo
AU  - Farina,Roberta
AU  - Catto,Marco
AU  - Iacobazzi,Rosa Maria
AU  - Nicolotti,Orazio
AU  - Cellamare,Saverio
AU  - Mangiatordi,Giuseppe Felice
AU  - Denora,Nunzio
AU  - Soto-Otero,Ramon
AU  - Siragusa,Lydia
AU  - Altomare,Cosimo Damiano
AU  - Carotti,Angelo
TI  - Exploring Basic Tail Modifications of Coumarin-Based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-Soluble, Brain-Permeant Neuroprotective Multitarget Agents
SN  - 1520-4804
PY  - 2017///0609
KW  - Acetylcholinesterase
KW  - metabolism
KW  - Animals
KW  - Cell Line, Tumor
KW  - Cell Survival
KW  - drug effects
KW  - Cholinesterase Inhibitors
KW  - chemical synthesis
KW  - Coumarins
KW  - Dogs
KW  - Dose-Response Relationship, Drug
KW  - Humans
KW  - Madin Darby Canine Kidney Cells
KW  - Molecular Structure
KW  - Monoamine Oxidase
KW  - Monoamine Oxidase Inhibitors
KW  - Neuroprotective Agents
KW  - Oxidative Stress
KW  - Solubility
KW  - Structure-Activity Relationship
KW  - Water
KW  - chemistry
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1021/acs.jmedchem.6b00562
ER  -