Laufer, Radoslaw <br/><br/>
Discovery of 4-(4-aminopyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamides as novel, highly potent and selective, orally bioavailable inhibitors of Tyrosine Threonine Kinase, TTK.  [electronic resource] 

 -  Bioorganic & medicinal chemistry letters  08 2016 
 - 3562-6 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1464-3405 
<br/><br/><label>Standard No.: </label>10.1016/j.bmcl.2016.06.021  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Administration, Oral<br/>Animals<br/>Antineoplastic Agents--administration & dosage<br/>Benzamides--administration & dosage<br/>Biological Availability<br/>Cell Cycle Proteins--antagonists & inhibitors<br/>Cell Death--drug effects<br/>Cell Line, Tumor<br/>Cell Proliferation--drug effects<br/>Dose-Response Relationship, Drug<br/>Drug Discovery<br/>Drug Screening Assays, Antitumor<br/>Humans<br/>Mice<br/>Models, Molecular<br/>Molecular Structure<br/>Protein Kinase Inhibitors--administration & dosage<br/>Protein Serine-Threonine Kinases--antagonists & inhibitors<br/>Protein-Tyrosine Kinases--antagonists & inhibitors<br/>Rats<br/>Structure-Activity Relationship<br/>Triazines--administration & dosage