Upregulation of Haploinsufficient Gene Expression in the Brain by Targeting a Long Non-coding RNA Improves Seizure Phenotype in a Model of Dravet Syndrome. [electronic resource]
- EBioMedicine Jul 2016
- 257-277 p. digital
Publication Type: Journal Article
2352-3964
10.1016/j.ebiom.2016.05.011 doi
Alleles Animals Base Sequence Behavior, Animal Brain--diagnostic imaging Cell Line Chlorocebus aethiops Disease Models, Animal Electroencephalography Epilepsies, Myoclonic--genetics Gene Expression Gene Knock-In Techniques Hippocampus--physiology Humans In Vitro Techniques Interneurons--metabolism Mice Mice, Transgenic Molecular Sequence Data NAV1.1 Voltage-Gated Sodium Channel--chemistry Nucleic Acid Conformation Oligonucleotides, Antisense--metabolism Patch-Clamp Techniques Phenotype RNA, Long Noncoding--antagonists & inhibitors Real-Time Polymerase Chain Reaction Sequence Alignment Sequence Analysis, RNA Temperature Up-Regulation Vero Cells Video Recording