TY  - GEN
AU  - Goldgof,Gregory M
AU  - Durrant,Jacob D
AU  - Ottilie,Sabine
AU  - Vigil,Edgar
AU  - Allen,Kenneth E
AU  - Gunawan,Felicia
AU  - Kostylev,Maxim
AU  - Henderson,Kiersten A
AU  - Yang,Jennifer
AU  - Schenken,Jake
AU  - LaMonte,Gregory M
AU  - Manary,Micah J
AU  - Murao,Ayako
AU  - Nachon,Marie
AU  - Murray,Rebecca
AU  - Prescott,Maximo
AU  - McNamara,Case W
AU  - Slayman,Carolyn W
AU  - Amaro,Rommie E
AU  - Suzuki,Yo
AU  - Winzeler,Elizabeth A
TI  - Comparative chemical genomics reveal that the spiroindolone antimalarial KAE609 (Cipargamin) is a P-type ATPase inhibitor
SN  - 2045-2322
PY  - 2018///0515
KW  - Amino Acid Sequence
KW  - Antimalarials
KW  - chemistry
KW  - Binding Sites
KW  - CRISPR-Cas Systems
KW  - genetics
KW  - Cytosol
KW  - Drug Resistance, Fungal
KW  - Indoles
KW  - Inhibitory Concentration 50
KW  - Molecular Docking Simulation
KW  - P-type ATPases
KW  - antagonists & inhibitors
KW  - Plasmodium falciparum
KW  - drug effects
KW  - Protein Structure, Tertiary
KW  - Proton-Translocating ATPases
KW  - Protozoan Proteins
KW  - Saccharomyces cerevisiae
KW  - Saccharomyces cerevisiae Proteins
KW  - Sequence Alignment
KW  - Sequence Analysis, DNA
KW  - Spiro Compounds
KW  - Structure-Activity Relationship
KW  - Whole Genome Sequencing
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S
UR  - https://doi.org/10.1038/srep27806
ER  -