Goldgof, Gregory M <br/><br/>
Comparative chemical genomics reveal that the spiroindolone antimalarial KAE609 (Cipargamin) is a P-type ATPase inhibitor.  [electronic resource] 

 -  Scientific reports  06 2016 
 - 27806 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. 
<br/><br/><label>ISSN: </label>2045-2322 
<br/><br/><label>Standard No.: </label>10.1038/srep27806  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Amino Acid Sequence<br/>Antimalarials--chemistry<br/>Binding Sites<br/>CRISPR-Cas Systems--genetics<br/>Cytosol--chemistry<br/>Drug Resistance, Fungal<br/>Indoles--chemistry<br/>Inhibitory Concentration 50<br/>Molecular Docking Simulation<br/>P-type ATPases--antagonists & inhibitors<br/>Plasmodium falciparum--drug effects<br/>Protein Structure, Tertiary<br/>Proton-Translocating ATPases--antagonists & inhibitors<br/>Protozoan Proteins--antagonists & inhibitors<br/>Saccharomyces cerevisiae--drug effects<br/>Saccharomyces cerevisiae Proteins--antagonists & inhibitors<br/>Sequence Alignment<br/>Sequence Analysis, DNA<br/>Spiro Compounds--chemistry<br/>Structure-Activity Relationship<br/>Whole Genome Sequencing