TY  - GEN
AU  - Davoren,Jennifer E
AU  - Lee,Che-Wah
AU  - Garnsey,Michelle
AU  - Brodney,Michael A
AU  - Cordes,Jason
AU  - Dlugolenski,Keith
AU  - Edgerton,Jeremy R
AU  - Harris,Anthony R
AU  - Helal,Christopher J
AU  - Jenkinson,Stephen
AU  - Kauffman,Gregory W
AU  - Kenakin,Terrence P
AU  - Lazzaro,John T
AU  - Lotarski,Susan M
AU  - Mao,Yuxia
AU  - Nason,Deane M
AU  - Northcott,Carrie
AU  - Nottebaum,Lisa
AU  - O'Neil,Steven V
AU  - Pettersen,Betty
AU  - Popiolek,Michael
AU  - Reinhart,Veronica
AU  - Salomon-Ferrer,Romelia
AU  - Steyn,Stefanus J
AU  - Webb,Damien
AU  - Zhang,Lei
AU  - Grimwood,Sarah
TI  - Discovery of the Potent and Selective M1 PAM-Agonist N-[(3R,4S)-3-Hydroxytetrahydro-2H-pyran-4-yl]-5-methyl-4-[4-(1,3-thiazol-4-yl)benzyl]pyridine-2-carboxamide (PF-06767832): Evaluation of Efficacy and Cholinergic Side Effects
SN  - 1520-4804
PY  - 2017///0529
KW  - Animals
KW  - Dose-Response Relationship, Drug
KW  - Drug Discovery
KW  - Female
KW  - Male
KW  - Mice
KW  - Models, Molecular
KW  - Molecular Structure
KW  - Picolinic Acids
KW  - chemical synthesis
KW  - Rats
KW  - Receptor, Muscarinic M1
KW  - agonists
KW  - Structure-Activity Relationship
KW  - Thiazoles
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1021/acs.jmedchem.6b00544
ER  -