A Novel HSP90 Inhibitor-Drug Conjugate to SN38 Is Highly Effective in Small Cell Lung Cancer. [electronic resource]
- Clinical cancer research : an official journal of the American Association for Cancer Research Oct 2016
- 5120-5129 p. digital
Publication Type: Journal Article
1557-3265
10.1158/1078-0432.CCR-15-3068 doi
Animals Antineoplastic Agents, Phytogenic--therapeutic use Apoptosis--drug effects Camptothecin--analogs & derivatives Carboplatin--therapeutic use Cell Cycle Checkpoints--drug effects Cell Line, Tumor DNA Damage--drug effects Drug Delivery Systems--methods Drug Synergism Female HSP90 Heat-Shock Proteins--antagonists & inhibitors Humans Irinotecan Lung Neoplasms--drug therapy Mice Mice, SCID Resorcinols--therapeutic use Signal Transduction--drug effects Small Cell Lung Carcinoma--drug therapy Xenograft Model Antitumor Assays