A novel arylbenzofuran induces cervical cancer cell apoptosis and G1/S arrest through ERK-mediated Cdk2/cyclin-A signaling pathway. [electronic resource]
- Oncotarget Jul 2016
- 41843-41856 p. digital
Publication Type: Journal Article
1949-2553
10.18632/oncotarget.9731 doi
Animals Apoptosis--drug effects Benzofurans--chemistry Cell Line, Tumor Cyclin A2--metabolism Cyclin-Dependent Kinase 2--metabolism Female G1 Phase Cell Cycle Checkpoints--drug effects HeLa Cells Humans Mice, Inbred BALB C Mice, Nude Mitogen-Activated Protein Kinase 1--metabolism Mitogen-Activated Protein Kinase 3--metabolism Molecular Structure Phytotherapy--methods Plant Extracts--chemistry Protein Kinases--metabolism Signal Transduction--drug effects Tumor Burden--drug effects Uterine Cervical Neoplasms--drug therapy Xenograft Model Antitumor Assays--methods