TY - GEN AU - Faria,Ellen C AU - Bercu,Joel P AU - Dolan,David G AU - Morinello,Eric J AU - Pecquet,Alison M AU - Seaman,Christopher AU - Sehner,Claudia AU - Weideman,Patricia A TI - Using default methodologies to derive an acceptable daily exposure (ADE) SN - 1096-0295 PY - 2017///0309 KW - Animals KW - Dose-Response Relationship, Drug KW - Drug Industry KW - history KW - Guidelines as Topic KW - Health Policy KW - History, 20th Century KW - History, 21st Century KW - Humans KW - Lethal Dose 50 KW - No-Observed-Adverse-Effect Level KW - Occupational Exposure KW - adverse effects KW - Occupational Health KW - Pharmaceutical Preparations KW - classification KW - Policy Making KW - Reproducibility of Results KW - Risk Assessment KW - Toxicity Tests N1 - Publication Type: Historical Article; Journal Article; Review UR - https://doi.org/10.1016/j.yrtph.2016.05.026 ER -