Blake, James F <br/><br/>
Discovery of (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one (GDC-0994), an Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical Development.  [electronic resource] 

 -  Journal of medicinal chemistry  06 2016 
 - 5650-60 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1520-4804 
<br/><br/><label>Standard No.: </label>10.1021/acs.jmedchem.6b00389  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Antineoplastic Agents--chemical synthesis<br/>Cell Proliferation--drug effects<br/>Dogs<br/>Dose-Response Relationship, Drug<br/>Drug Discovery<br/>Drug Screening Assays, Antitumor<br/>HCT116 Cells<br/>Humans<br/>Mice<br/>Mitogen-Activated Protein Kinase 1--antagonists & inhibitors<br/>Mitogen-Activated Protein Kinase 3--antagonists & inhibitors<br/>Molecular Structure<br/>Neoplasms, Experimental--drug therapy<br/>Protein Kinase Inhibitors--chemical synthesis<br/>Pyridones--chemical synthesis<br/>Pyrimidines--chemical synthesis<br/>Rats<br/>Structure-Activity Relationship