TY - GEN AU - Zhang,Liyong AU - Xiang,Wenpei AU - Wang,Guoliang AU - Yan,Zhengzheng AU - Zhu,Zhaowei AU - Guo,Zhong AU - Sengupta,Rajib AU - Chen,Alex F AU - Loughran,Patricia A AU - Lu,Ben AU - Wang,Qingde AU - Billiar,Timothy R TI - Interferon β (IFN-β) Production during the Double-stranded RNA (dsRNA) Response in Hepatocytes Involves Coordinated and Feedforward Signaling through Toll-like Receptor 3 (TLR3), RNA-dependent Protein Kinase (PKR), Inducible Nitric Oxide Synthase (iNOS), and Src Protein SN - 1083-351X PY - 2017///0410 KW - Adaptor Proteins, Vesicular Transport KW - deficiency KW - Animals KW - Cells, Cultured KW - Endosomes KW - drug effects KW - Hepatocytes KW - Interferon-beta KW - biosynthesis KW - Lipopolysaccharides KW - pharmacology KW - Mice KW - Mice, Inbred C57BL KW - Mice, Knockout KW - Models, Biological KW - Nitric Oxide Synthase Type II KW - Phosphorylation KW - Poly I-C KW - RNA Interference KW - RNA, Double-Stranded KW - immunology KW - Signal Transduction KW - Toll-Like Receptor 3 KW - Tyrosine KW - chemistry KW - Up-Regulation KW - eIF-2 Kinase KW - src-Family Kinases KW - antagonists & inhibitors N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural UR - https://doi.org/10.1074/jbc.M116.717942 ER -