Zhang, Liyong

Interferon β (IFN-β) Production during the Double-stranded RNA (dsRNA) Response in Hepatocytes Involves Coordinated and Feedforward Signaling through Toll-like Receptor 3 (TLR3), RNA-dependent Protein Kinase (PKR), Inducible Nitric Oxide Synthase (iNOS), and Src Protein. [electronic resource] - The Journal of biological chemistry 07 2016 - 15093-107 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

1083-351X

10.1074/jbc.M116.717942 doi


Adaptor Proteins, Vesicular Transport--deficiency
Animals
Cells, Cultured
Endosomes--drug effects
Hepatocytes--drug effects
Interferon-beta--biosynthesis
Lipopolysaccharides--pharmacology
Mice
Mice, Inbred C57BL
Mice, Knockout
Models, Biological
Nitric Oxide Synthase Type II--deficiency
Phosphorylation--drug effects
Poly I-C--pharmacology
RNA Interference
RNA, Double-Stranded--immunology
Signal Transduction--drug effects
Toll-Like Receptor 3--deficiency
Tyrosine--chemistry
Up-Regulation--drug effects
eIF-2 Kinase--deficiency
src-Family Kinases--antagonists & inhibitors